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Only a few remains of the three-nave gallery basilica, built by Pope Leo III (795-816) in place of an earlier titulus, can still be recognized in the existing wall structures. The present building and its liturgical furnishings result from a reconstruction carried out in 1475 under Pope Sixtus IV and a refurbishment in 1596-1597, commissioned by the historian and antiquarian Cesare Baronio (1538-1607), titular cardinal of SS. Nereo e Achilleo. Baronio had elements of liturgical furnishings from the 12th and 13th centuries, that had been dismanteled during the post-Tridentine renovations in several Roman churches, transferred into this church and reassembled: These include the two presbytery screens (plutei), the altar front, the fenestella confessionis, parts of the throne with its lions, portions of the opus sectile pavement of the presbytery, and reassembled cosmatesque fragments in the pulpit stairs. The mosaics have been extensively supplemented and renewed. The resulting “pastiche” combines medieval fragments from S. Giovanni in Laterano, S. Giovanni Calibita, S. Silvestro in Capite, S. Paolo fuori le mura, and possibly also from the basilica of SS. Nereo and Achilleo itself.