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S. Maria in Portico was an important church located in the densely populated area between the Theatre of Marcellus and S. Maria in Cosmedin. Its origins are obscure, but are traditionally linked to the legend of a Marian apparition in the house of St. Galla Patrizia, daughter of the consul Simmachus. A church is said to have been founded on the site of her house during the pontificate of Pope John I (523-526). S. Maria in Portico is first mentioned in 1106 but is older. The altar - a reused Roman funeral altar preserved today in S. Galla, with an inscription by Pope Gregory VII dated 1073 - suggests a foundation of the church at that time. It is a basilica with three naves, divided by arcades on columns intersected by pillars, with a non-protruding transept and a south-facing apse. In the Liber Censuum of Cencio Camerario (1192), it is listed among the richest Roman churches. In 1256, Pope Alexander IV consecrated the church and its altar, depositing relics of various saints. The legend of the miraculous Madonna was associated with the image of the icon, which dates back to the 13th century. The ciborium of the high altar, documented in a drawing, contained a tabernacle in its upper level to store the icon. The church underwent various renovations and restorations over the centuries, especially during the Renaissance and Baroque periods. In 1662, under Pope Alexander VII, the church was demolished. The icon of the Madonna and many relics with their precious reliquaries were transferred to the new church of S. Maria in Campitelli, where they are still venerated today.