Historical information on the church is scarce. In the 12th century it was under the patronage of S. Pietro in Vincoli, from which it tried in vain to emancipate itself. In 1156, Pope Hadrian IV (1154-1159) resolved the issue in favour of S. Pietro in Vincoli. In 1192, the church is mentioned by Cencio Camerario. Due to limited financial resources, Pope Nicholas IV (1288-1292) limited the number of clerics to a maximum of two. In the 16th century, the church was abandoned, and Chacón describes it as a ruin. No information is available about the appearance of the building, but two inscriptions presented in 1936 by Cardinal Giovanni Mercati suggest a renovation of the liturgical furnishings in 1236 under Pope Gregory IX (1227-1241). The inscription (possibly on a ciborium) handed down by a Silloge mentions the work of the marble artisan Angelus de Trivio.