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The small church, consecrated in 1220, stands on the ancient path from the Abbazia delle Tre Fontane to S. Sebastiano and was frequented by pilgrims on their way to Rome in the 14th century. From 1518, it was run by the Archconfraternity of the Gonfalone. In 1935 the Nunziatella became a parish and in 1965 a diaconate. The floor in front of the choir area appears cosmatesque at first glance, but does not match any of the 13th century Roman urban floors. Although a certain symmetry can be recognised as a general organising principle, the individual elements are often incomplete or arranged asymmetrically. The central axis is dominated by a not particularly large quincunx, but neither here nor in the other parts are the otherwise typical and essential strips of white marble to be found. The often seemingly random arrangement is not so much attributable to later restorations, but rather to the unprofessional laying of reused material. The church received its re-used opus sectile floor some time between 1220 and 1518. At the end of the left longitudinal wall is a marble medieval tabernacle (78 x 50 cm); it is a rather crude work, of which there is no equivalent in Rome. The small bell tower also dates to the 13th century.